عرض تفاصيل البحث

ادناه جميع التفاصيل الخاصة بالبحث المطلوب عرضه. توفر هذه المنصة معلومات اساسية حول البحث, لمزيد من التفاصيل يرجى متابعة التصفح من خلال الضغط على الرابط الاصلي للبحث او رابط DOI.

عنوان البحث
In Vitro Quality Assessment And Antibacterial Efficacy Of Ciprofloxacin Tablets From Different Pharmaceutical Companies In Community Pharmacies In Iraq
عنوان المجلة
Journal Of Pharmaceutical Negative Results
ISSN-2229-7723
تفاصيل النشر
سنة النشر - 2022 / الفهرس الاصلي للمجلة - 13 : 2 (عدد الصفحات 9)
تصنيف البحث
Biomedical sciences - المجموعة الطبية
رابط DOI
#
رابط البحث
فتح في موقع المجلة الرسمي
البحث والاستدامة
الهدف 3 – الصحة الجيدة والرفاه   المزيد حول هذا الهدف
البحث والمجتمع
نعم , يدعم
الكلمات المفتاحية
Antibacterial Activity., Ciprofloxacin, Dissolution Rate, MIC, Quality Assessment, Quality Control

اسم الباحثجهة الانتساببلد الباحث
فاطمة عدنلن الزبيدي كلية الصيدلة العراق
رفل جليل الصائغ كلية الصيدلة العراق
ايناس نجم عبيد كلية الصيدلة العراق
خارس لييابي جامعة اثينا الوطنية اليونان
حسام وهاب الحمادي كلية الصيدلة العراق

Introduction: Bioequivalence and bioavailability of antimicrobial drugs are considered as a critical issue in treatment of infectious diseases. Recently, some variations have been detected in clinical response to some antimicrobial agents. Ciprofloxacin is one of broad spectrum bactericidal agent that has been used widely in community which motivate us to assess its quality and quantity within available brands. Methods: Ciprofloxacin tablets from brand company (A) and other generic companies (B, C and D) have been selected, a standard powder in specific amount was dissolved and injected directly into HPLC to interpolate with the quantity of ciprofloxacin from each company tablet. In vitro dissolution rate was evaluated in every sample by calculating the difference and similarity factors. Antimicrobial effect was evaluated by minimum inhibitory concentration (MIC) method for reference strains of low to high level quinolone resistant bacteria. Results: Ciprofloxacin content was approved within accepted range for all companies except D that exceed the rang value. The dissolution testing was very rapid for A and B (>85%) within 15 minutes, while for D was <80% during the first 30 minutes. MIC for 24 hours of 0.128500mg/L ciprofloxacin for all strains showed better results seen in A and B than D. Original ArticleOrignal Article Conclusion: Ciprofloxacin tablet of A, B and C companies were approved under the light of the quality test and antibacterial efficacy in comparison with D company, that urge for continuous monitoring and evaluation the generic drugs to avoid drug usefulness and antibiotic resistance