عرض تفاصيل البحث

ادناه جميع التفاصيل الخاصة بالبحث المطلوب عرضه. توفر هذه المنصة معلومات اساسية حول البحث, لمزيد من التفاصيل يرجى متابعة التصفح من خلال الضغط على الرابط الاصلي للبحث او رابط DOI.

عنوان البحث
The Impact Of Vitamin D Deficiency On Some Immunomodulatory Markers In Pregnant Women With Threatened Abortion
عنوان المجلة
Azerbaijan Medical Journal
ISSN-0005-2523
تفاصيل النشر
سنة النشر - 2022 / الفهرس الاصلي للمجلة - 62 : 4 (عدد الصفحات 11)
تصنيف البحث
Biomedical sciences - المجموعة الطبية
رابط DOI
#
رابط البحث
فتح في موقع المجلة الرسمي
البحث والاستدامة
الهدف 3 – الصحة الجيدة والرفاه   المزيد حول هذا الهدف
البحث والمجتمع
نعم , يدعم
الكلمات المفتاحية
Vitamin D, Pregnancy, Threatened Abortion, IL-6, TNF-?, INF-?

اسم الباحثجهة الانتساببلد الباحث
رفل جليل الصائغ كلية الصيدلة العراق
ايناس نجم عبيد كلية الصيدلة العراق
ندى خزعل هندي كلية التمريض العراق
أحمد حسام الحمادي جامعة اثينا الوطنية اليونان
حسام وهاب الحمادي كلية الصيدلة العراق

The protective mechanism of vitamin D (VD) on the immune system played an important role behind many health problems including abortion. Our aim was to investigate the levels of VD and some immunomodulatory markers (IL-6, TNF- and INF-) in pregnant women with threatened abortion (TA) and their effects on their obstetric health. This study including 132 pregnant participants with TA visiting maternity hospital in Babel province, Iraq. The demographic data including previous and current obstetrical history and body mass index were collected by well-trained researcher following structured questionnaire after obtaining their verbal consent. Laboratory Investigations were done with estimation of VD, IL-6, TNF- and INF- . The mean level of VD was 19.83±43.59 ng/ml while the mean levels of IL-6: 389.45±70.88, TNF-: 118.78±44.11 and INF-: 100.39±20.13 pg/ml with related percentage among participants for low VD was 84%, high IL-6 was 66%, high TNF- was in 43% but only 23% had high INF- in relation with normal values. The frequency of abortion was significantly increased with low VD and high IL-6 (p<0.05) with high correlation between them (r2=0.89). High incidence of TA associated with low level of VD accompanied with high serum levels of IL-6. This adverse pregnancy outcome may be associated with some form of autoimmune diseases with evidence that hypovitaminosis D was correlated with high proinflammatory markers (IL-6, TNF- and IFN-) and worse form of TA and the role of VD is to correct these proinflammatory markers