عرض تفاصيل البحث

ادناه جميع التفاصيل الخاصة بالبحث المطلوب عرضه. توفر هذه المنصة معلومات اساسية حول البحث, لمزيد من التفاصيل يرجى متابعة التصفح من خلال الضغط على الرابط الاصلي للبحث او رابط DOI.

عنوان البحث
Evaluation The Antioxidant Enzymes Activity In Adults Male Rats Treated With Some New 3-Mercapto1,2,4-Triazole Derivatives
عنوان المجلة
Journal Of Pharmacy And Technology
ISSN-0974-3618
تفاصيل النشر
سنة النشر - 2022 / الفهرس الاصلي للمجلة - 15 : 1 (عدد الصفحات 4)
تصنيف البحث
علوم الكيمياء - المجموعة الطبية
رابط DOI
#
رابط البحث
فتح في موقع المجلة الرسمي
البحث والاستدامة
الهدف 3 – الصحة الجيدة والرفاه   المزيد حول هذا الهدف
البحث والمجتمع
نعم , يدعم
الكلمات المفتاحية
Triazole, Mercapto, Antioxidant, Glutathione peroxidase, Oxidative stress

اسم الباحثجهة الانتساببلد الباحث
عاصم علاء عبد الحسين سلمان كلية الصيدلة العراق

Three 1,2,4-triazole derivatives B, D, and E were evaluated their effect on the activity of antioxidant enzymes glutathione peroxidase (GPX) and superoxide dismutase (SOD) in vivo serum and liver injury in mice that exposed to thioacetamide. Male rats of the present experiment were randomly divided into six equal groups. First group (C-) the animals were received normal saline as a negative control. Other five groups: C+ and T1-T4 exposed to oxidative stress by thioacetamide 100 mg/kg. The four animals groups T1, T2, T3 and T4 were received thioacetamide 100 mg/kg and treated orally with 0.21 mg/kg daily with ascorbic acid (A), compound B, compound D and compound E, respectively. The experiment was carried out for eight weeks. The results indicated that the tested compounds exhibited remarkable antioxidant activity. The highest activity of SOD enzyme values was recorded of compound D 2665 IU/L compared to ascorbic acid as a standard antioxidant agent 1657 IU/L. On the other-hand the increasing in the activity of GPX enzyme value was recorded after administration of compound D 2010 IU/L compared to ascorbic acid as a reference antioxidant agent 1682 IU/L at the same conditions. Significant differences in the responses of antioxidant enzymes to the different types of tested compounds were probably due to by the variant number and site of functional group in structure of studied compounds. The results suggested that alteration in enzymes activities may be applicable to the capacity of the liver and other inspected organs to cope with oxidative stress poisoned thioacetamide. The results of current study concluded that compounds B and D appeared clear improvement in scavenging activity to modulate toxicity of thioacetamide and regeneration of hepatocyte as well as normalized body function. Altogether, the results that were obtained from the present study could lead to design of new potent molecules via development of them in future studies.